منابع مشابه
The Succinated Proteome of FH-Mutant Tumours
Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through various, but not necessarily mutually exclusive, mechanisms. One such mechanism, succination, is an...
متن کاملAn Investigation of Mitochondrial Bioenergetics and the Turnover of Succinated Proteins in the Adipocyte during Diabetes
iii Dedication I would like to dedicate this thesis to my parent's Robert and Marie Tanis as well as my brother James Tanis. With their support I have always been given the opportunity to pursue my dreams and goals. My mentor Dr. Norma Frizzell has made all of this possible by allowing me the opportunity to pursue my Master's Degree in her laboratory, for which I will always be grateful. iv Ack...
متن کاملThe Human Proteome Organization: a mission to advance proteome knowledge.
With the completion of the genome project, it has been viewed that the proteome is the next major challenge. With heightened expectations comes the need for organizing public effort. The Human Proteome Organization (HUPO) was founded to regroup scientists in the public and private sectors engaged worldwide in various aspects of proteomics. Over the past year, HUPO has strived to develop a missi...
متن کاملThe Phagosome Proteome
Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins. Using a proteomic approach, we identified >140 proteins associated with latex bead-containing phagosomes. Among ...
متن کاملThe plastic proteome
The plastic proteome S accharomyces cerevisiae is a hardy species, able to survive in a variety of tough environments. By systematically tracking the levels and local-ization of proteins in individual cells, Breker et al. reveal how yeast dramatically remodel their proteome to adapt to different conditions (1). Many studies have used microarrays or deep sequencing to map yeast cells' tran-scrip...
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ژورنال
عنوان ژورنال: Mass Spectrometry Reviews
سال: 2013
ISSN: 0277-7037
DOI: 10.1002/mas.21382